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Pulmonary embolism (PE) is the leading trigger of in-hospital death and the third most frequent cause of cardiovascular death. The clinical presentation of PE is variable, and choosing the suitable therapy for individual patients could be challenging. Traditionally, treatment of PE has involved a alternative of anticoagulation, thrombolysis or surgical procedure; however, a range of percutaneous interventional technologies have been developed that are underneath investigation in patients with intermediate-high-threat or excessive-threat PE. These interventional applied sciences include catheter-directed thrombolysis (with or without ultrasound help), aspiration thrombectomy and combinations of the aforementioned ideas. These interventional treatment choices may lead to a more speedy improvement in right ventricular function and pulmonary and/or systemic haemodynamics particularly patients.